PhD Student (gn*) Life Sciences, Biotechnology or Biomedicine
Fixed-term for 3 years | Part-time at 65% | Salary according to TV-L E13 | Department of Medicine D
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Department of Medicine D – ideally with you on board!
Chronic kidney diseases are among the ten most common causes of death worldwide. Highly specialized podocytes play a central role in the kidney’s filtration function. Many nephrotic syndromes are caused by genetic variants in podocyte-specific proteins. One of these is Crumbs2, an apical polarity and cell-contact protein whose loss leads to damage of the kidney filtration barrier and can ultimately result in chronic kidney disease.
This project investigates the crosstalk between apical cell contacts – depending on Crumbs2 – and focal adhesions in podocytes. Genetically modified mouse models and cell lines as well as high-resolution microscopy, molecular biology methods, transcriptomic analyses, and proteomic analyses will be used to address this research question.
RESPONSIBILITIES:
- Working with genetically modified mouse lines
- Processing and analysis of transcriptomic and phosphoproteomic samples from murine tissue and cell cultures
- Application of high-resolution microscopy techniques
- Complex genetic modification of cell lines
- Molecular and cell biological analyses to investigate podocytes
REQUIREMENTS:
- Completed university degree (M.Sc.) in Life Sciences, Biotechnology, Biochemistry or Biomedicine
- Very good knowledge of molecular and cell biology
- Practical experience with cell culture
- Willingness to conduct animal-based research as part of the research project
- Good knowledge of confocal microscopy
- Very good command of English
- Independent, structured and goal-oriented approach to work as well as reliability and team orientation
WE OFFER:
- Salary according to TV-L E13, Extra annual payment, and company pension plan (VBL)
- 30 days of vacation per year, plus two additional days off on Christmas Eve and New Year's Eve
- A wide range of training and professional development opportunities
- A well-equipped laboratory and close individual supervision
- Integration into a graduate school
- A respectful and appreciative work environment within an interdisciplinary team of biologists and physicians
- Support and advisory services for health and work-life balance
- Additional benefits such as sports programs, job ticket, jobrad, company events, cafeteria, and emergency childcare
For inquiries, please contact: Dr. Annika Möller-Kerutt, Project Leader, T +49 251 83-44967
Apply now via our career portal.
▼ Further Information
Information regarding the application process
Equal Opportunities:
Equal opportunities are an integral part of our HR policy. UKM supports the compatibility of career and family life and has been certified as a family-conscious employer since 2010. In principle, part-time employment is possible. In areas where women are underrepresented, they will be given preferential consideration in accordance with statutory provisions, provided they have equal qualifications, aptitude, and professional performance. Applicants with severe disabilities will also be given preferential consideration under the same conditions and within the framework of legal regulations.
Further Information:
- Due to the legal requirements of the German Measles Protection Act, employment with us is only possible with full vaccination protection against measles.
- We reserve the right to close the selection process as soon as a suitable candidate has been found.
- Applications submitted by email or post cannot be considered.
- Salary according to TV-L. Classification is based on the assigned responsibilities and qualifications. Placement within the pay scale levels is determined according to relevant professional experience.
Notice to Recruitment Agencies:
UKM already cooperates with selected recruitment agencies on the basis of framework agreements. We therefore kindly ask you to refrain from submitting unsolicited offers. Information on tender procedures can generally be found on the NRW procurement platform.
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